Silicycle SiliaMetS and SiliaBond Functionalised Silicas

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Metal and Organic Scavenger Chart

SiliaMetS Metal Scavengers

SiliaMetS - silica gels functionalised with chemical handles for reacting with and trapping metals present in your reactions.

Which SiliaMetS agent do I need?

Decide which metal you wish to scavenge.
Use this chart to determine which SiliaMetS agents are compatible with your metal.
Watch this video to see how easy it is to use the SiliaMetS agents.

Why SiliaMetS?

Compatible with any organic/aqueous solvent (pH 2-12)
Mechanically stable under vigorous stirring
Remove using simple filtration
Microwave compatible
No loss of API
Fast kinetics/low-cost

Literature example:

A process chemistry case-study utilising the SiliaMetS-Thiol to reduce Cu levels to 1 ppm. https://pubs.acs.org/doi/pdf/10.1021/op050251y

Consult this chart to determine the best scavenger for your target metal.

SiliaMetS Cysteine

5 g / £42

R80530B

SiliaMetS TAAcOH

5 g / £42

R69030B

SiliaMetS DMT

5 g / £42

R79030B

SiliaMetS TAAcONa

5 g / £42

R69230B

SiliaMetS Imidazole

5 g / £42

R79230B

SiliaMetS Thiol

5 g / £42

R51030B

SiliaMetS Triamine

5 g / £42

R48030B

SiliaMetS Thiourea

5 g / £42

R69530B

Universal Scavenger Kit (K30730B): 5g of all eight scavengers shown above for £285.

Larger pack sizes available. Please enquire for 10 g, 25 g, 50 g, 100 g, 250 g, 500 g and 1 kg.

SiliaBond Peptide Synthesis Reagents and Organic Scavengers

SiliaBond - silica gels functionalised for use as synthetic reagents or as organic scavengers.

Which SiliaBond agent do I need?

Use this chart to determine which SiliaMetS agents are compatible with your metal.

Why SiliaBond?

Easy isolation of product through filtration / no API loss
Can eliminate the need for column chromatographic purification
Mechanically stable under vigorous stirring - no leaching
Remove using simple filtration
Thermally stable
Fast kinetics/low-cost

Literature example:

Rapid analogue generation through parallel synthesis enabled by the use of SiliaBond-carbodiimide and Siliabond-carbonate for amide couplings: https://www.pnas.org/doi/full/10.1073/pnas.1015255108

SiliaBond Carbodiimide

10 g / £90

R70530B

SiliaBond DMAP

10 g / £130

R75630B

SiliaBond Carbonate

10 g / £80

R66030B

SiliaBond Amine (WAX)

10 g / £55

R52130B

SiliaBond Piperazine

10 g / £81

R60530B

SiliaBond Carboxylic Acid (WCX)

R70030B

10 g / £55

SiliaBond Tosic

Acid (SCX)

R60530B

10 g / £55

SiliaBond Propylsulfonic Acid (SCX-2)

R51230B

5 g / £55

SiliaBond carbodiimide - synthesis of amides, esters, and activated esters.

SiliaBond DMAP - use analogously to 4-dimethylaminopyridine as a nucleophilic catalyst for acylation, amidation or acetylation.

SiliaBond carbonate - silica bound analogue of tetramethyl ammonium carbonate. Use as a general base to quench a reaction, scavenge acids and excess HOBt in amide coupling reactions.

SiliaBond amine - use as a weak anion exchanger or to scavenge acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles.

SiliaBond Piperazine - deprotecting Fmoc and Bsmoc amino protecting groups and as a solid-phase Knoevenagel catalyst. May also be used to scavenge electrophiles.

SiliaBond carboxylic acid - use as a weak cation exchanger or to scavenge amines or carbonates, and quench alkoxides and organometallic reagents.

SiliaBond tosic acid - use as a strong cation exchanger or as a solid-supported strong acid with a pka <1. Can scavenge amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions. Serves as an alternative for quenching reactions instead of aqueous/organic soluble acids.

SiliaBond propylsulfonic acid - use as a strong cation exchanger or to scavenge amines and other basic functionalities.

Larger pack sizes available. Please enquire for 10 g, 25 g, 50 g, 100 g, 250 g, 500 g and 1 kg.

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